Résumé de communication

Objectives: This presentation aims at providing a comprehensive overview of the evolving landscape of Plant-Derived Exosomes-like Nanoparticles and their transition to Plant Stem Cells-derived Exosomes. The audience will gain insights into the historical context of extracellular vesicles research, the current understanding of the unique properties of these nanoparticles, and potential future directions of their indications in the realm of aesthetic and regenerative medicine. Introduction: In the context of the growing significance of exosomes in regenerative medicine, ethical and sustainability questioning from the public and the physicians’ community has raised, providing rationale for exploring plant-derived exosomes-like nanoparticles, their potential advantages over other sources and the need for a comprehensive understanding of their evolution to plant stem cells-derived exosomes. The relevance and implications of this evolutionary process in the field of aesthetic and regenerative medicine are also highlighted. Materials / method: By conducting a comprehensive and systematic review of current research in the field of plant-derived exosomes, with criteria including good quality study designs, peer-reviewed publications and clinical trials, the evolution in this field has been traced and contemporary advancements compiled independently of any industry. By reviewing extraction and characterization of plant-derived exosomes-like nanoparticles, as well as the cultivation and isolation of exosomes from plant stem cells, the properties and efficacy of the different methods were outlined. Results: Plant-derived extracellular vesicles are evidenced to successfully mediate intercellular communication through naturally occurring bioactive components and exogenous bioengineered cargo, customised with biomimetic actives, proteins, peptides, amino-acids, growth factors, liposomes addressing specific indications. Efficacy on inflammation, pigmentation, skin regenerative functions, collagen and elastin synthesis, angiogenesis, wound healing, cutaneous immune responses to external environment are found across studies. These findings elucidate current state of knowledge on plant-derived exosomes Conclusion: Bioactive nanovesicles released from plants show remarkable anti-inflammatory and regenerative properties. They comprise a variety of bioactive molecules, potential to deliver their nano-cargo to human skin inducing anti-inflammatory, antioxidant, and regenerative activity. Clinical challenges ahead offer perspective on evolution of plant stem cells-derived exosomes, their promising broader implications as alternative cell-free approach in regenerative medicine, aesthetic procedures but also in cutting-edge cosmeceuticals. Future research will surely propel the field of plant exosomes forward.