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Objectives: This study aims to provide a comprehensive overview of exosomes' emerging role in dermatology and aesthetic medicine, highlighting their potential therapeutic applications. Introduction: Exosomes are nanoscale vesicles derived from cells, recognized in regenerative medicine for their capability to transport diverse biomolecules such as proteins, nucleic acids, and lipids. These vesicles are key mediators of intercellular. communication, impacting critical cellular processes including proliferation, differentiation, migration, and cell death. Materials / method: Leveraging our extensive experience in exosome-based treatments for over 2000 patients, this study synthesizes recent research to outline the mechanisms and potential applications of exosomes in various dermatological and aesthetic procedures. Results: Exosomes show promise as therapeutic agents in a broad spectrum of dermatological and aesthetic interventions, including wound healing, scar management, skin aging reversal, facial rejuvenation, pigmentation issues, psoriasis, atopic dermatitis, vitiligo, lupus, sclerosis, and hair growth. Their multifaceted mechanisms offer versatile solutions for numerous dermatological conditions and aesthetic improvements. Conclusion: The growing research on exosomes underscores their transformative potential in dermatology and aesthetic medicine. Harnessing exosomes' regenerative properties could revolutionize treatment approaches for various skin conditions and aesthetic. needs. Further research is encouraged to fully unlock their therapeutic potential and innovate clinical applications.