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Objectives: Objective This lecture aims to explore the innovative use of autologous fat grafting and adipose-derived cells in hair regeneration. Attendees will gain a comprehensive understanding of the science, techniques, and clinical applications of this emerging field, with a focus on achieving effective hair restoration outcomes. Learning Outcomes Understanding Adipose-Derived Cells Participants will gain a detailed understanding of the biology and properties of adipose-derived cells, including their role in tissue regeneration and repair. Discussion on the differentiation potential and regenerati Introduction: Hair loss affects millions worldwide, significantly impacting self-esteem and quality of life. Conventional hair restoration techniques, including medications, PRP (Platelet-Rich Plasma), and hair transplantation, often yield variable results and may not be suitable for all patients. Recent advances in regenerative medicine have highlighted the potential of autologous fat grafting and adipose-derived cells (ADCs) in stimulating hair regeneration. These cells, rich in mesenchymal stem cells, growth factors, and regenerative properties, have shown promising results in promoting hair Materials / method: Between 2018 and 2023, 68 patients (45 males, 23 females) with androgenetic alopecia or early-stage alopecia were treated with autologous fat grafting enriched with mechanically isolated adipose-derived cells. Fat was harvested from the abdomen or flanks using manual liposuction under tumescent anesthesia. The fat was washed and processed using a mechanical dissociation technique to isolate the stromal vascular fraction (SVF), containing ADCs, without the use of enzymes. The processed fat, enriched with ADCs, was injected into the scalp targeting areas of hair thinning and miniaturized follicl Results: At 6 months, 81% of patients demonstrated increased hair density and improved hair shaft thickness in treated areas. Trichoscopic evaluation revealed an average hair count increase of 18-25% compared to baseline. Hair quality, scalp health, and patient-reported satisfaction showed notable improvements, with 76% of patients expressing satisfaction with the visible results at 6 months and 85% at 12 months. No major complications were observed. Minor side effects included transient scalp swelling and tenderness, resolving within 7-10 days. Compared to PRP alone or conventional treatments, patient Conclusion: Autologous fat grafting enriched with mechanically isolated adipose-derived cells offers a promising, minimally invasive, and regenerative approach to hair restoration. The mechanical dissociation technique avoids the need for enzymatic processing, making it safe, reproducible, and suitable for clinical settings. While initial results are encouraging, larger controlled studies and long-term follow-up are needed to further validate the efficacy and durability of this technique. Nonetheless, ADC-enriched fat grafting represents a significant step forward in innovative, cell-based therapies for h