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Objectives: The objectives of this article are to pioneer a paradigm shift in aesthetic medicine through the innovative application of regenerative techniques that prioritize the preservation and enhancement of the extracellular matrix (ECM) and the use of myomodulation as a proactive strategy against aging. By introducing the HydroTox Mesoblend method, this study demonstrates a cutting-edge approach that marries ECM support with muscle relaxation to deliver natural, long-lasting results, setting new standards in skin health preservation. This groundbreaking technique opens avenues for broader application Introduction: The quest for a youthful neck has evolved beyond traditional volume enhancements to address deeper aging mechanisms. Regenerative aesthetics now focus on skin quality and structural revitalization. This study introduces HydroTox Mesoblend, a novel technique combining CPM-HA20G and incobotulinum toxin. By hydrating the extracellular matrix with hyaluronic acid and improving myomodulation, this dual-action approach smooths and rejuvenates the neck and lower third of the face. Evaluated for efficacy and safety in Mexican subjects, HydroTox Mesoblend sets a new standard in in preventive care. Materials / method: This pilot study in Mexico evaluated the efficacy of a novel intradermal injection technique using a 30Gx4mm needle to deliver 1.5 ml of Hydrotox mesoblend into the neck and lower face. The mesoblend, combining CPM®-HA20G and 100 IU incobotulinum toxin, was applied in 0.05 ml per injection. Topical lidocaine was used for pain relief. Corneometry and US elastography assessed skin hydration and elasticity at 15 and 180 days. Outcomes were measured using the Global Aesthetic Improvement Scale with unexpected DAO muscle improvement observed thanks to myomodulation. Results: Results showed significant improvements in skin hydration, elasticity, wrinkle reduction, neck lines, muscle strength, and overall aesthetic appearance, as reflected on the GAIS scale. Corneometry indicated increased hydration, while elastography revealed reduced tissue rigidity. A single treatment session had a cumulative effect, enhancing skin firmness by 180 days. No serious adverse events were reported. Patients rated pain at 3/10 on the VAS. Notably, there was significant improvement in the lower facial third, particularly in the DAO muscle. Conclusion: This study demonstrates the clinical efficacy and safety of the HydroTox Mesoblend technique, combining CPM®-HA20G with incobotulinum toxin, with no adverse skin reactions. The hyaluronic acid formulation showed prolonged action and improved tissue integration. The focus was on skin revitalization and myomodulation, with potential broader applications such as the décolletage and fine lines. Driven by regenerative medicine principles, the technique supports skin health through minimally invasive procedures. Future studies are needed to further evaluate safety, effectiveness, and duration.